ACHN 2017 Annual Report

Incorporated by Reference Exhibit No. Description Form SEC Filing date Exhibit Number Filed with this 10-K 10.6 Amendment No. 3 to Lease, dated as of August 20, 2015, by and between the Registrant and WE George Street, LLC. 8-K 08/24/15 10.1 10.7 Amendment No. 4 to Lease, dated as of April 7, 2016, by and between the Registrant and WE George Street, LLC. 8-K 04/08/16 10.1 10.8 Amendment No. 5 to Lease, dated as of October 3, 2017, by and between the Registrant and WE George Street, LLC. 10-Q 11/01/17 10.2 # 10.9 2006 Stock Incentive Plan as amended September 18, 2006, March 9, 2010, June 10, 2010, April 11, 2012 and June 5, 2012. 8-K 06/11/12 99.3 # 10.10 Form of Nonstatutory Stock Option Agreement under the 2006 Stock Incentive Plan. 8-K 12/22/10 99.1 # 10.11 Form of Incentive Stock Option Agreement under the 2006 Stock Incentive Plan. 8-K 12/22/10 99.2 # 10.12 2015 Stock Incentive Plan, dated June 2, 2015. 8-K 06/08/15 10.1 # 10.13 Form of Incentive Stock Option Agreement under the 2015 Stock Incentive Plan. 10-K 02/25/16 10.16 # 10.14 Form of Nonstatutory Stock Option Agreement under the 2015 Stock Incentive Plan. 10-K 02/25/16 10.17 # 10.15 Amended and Restated Employment Agreement, dated August 4, 2017, by and between the Registrant and Milind S. Deshpande. 10-Q 08/08/17 10.1 # 10.16 Amended and Restated Employment Agreement, dated August 4, 2017, by and between the Registrant and Mary Kay Fenton. 10-Q 08/08/17 10.2 # 10.17 Amended and Restated Employment Agreement, dated August 4, 2017, by and between the Registrant and Joseph Truitt. 10-Q 08/08/17 10.4 # 10.18 Amended and Restated Employment Agreement, dated August 4, 2017, by and between the Registrant and Martha Manning. 10-Q 08/08/17 10.5 # 10.19 Non-Executive Directors Compensation Policy, dated March 28, 2017. 10-Q 05/04/17 10.1 10.20 Controlled Equity Offering SM Sales Agreement, dated as of February 23, 2017, by and between the Registrant and Cantor Fitzgerald & Co. 10-K 02/23/17 10.27 10.21 Letter Agreement, dated February 23, 2017, by and between the Registrant and Johnson & Johnson Innovation-JJDC, Inc. 10-K 02/23/17 10.28 10.22 Letter Agreement, dated November 14, 2017, by and between the Registrant and Johnson & Johnson Innovation- JJDC, Inc. 8-K 11/16/17 10.1 99

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