i COMPUTER PROGRAMS AND SYSTEMS, INC. 6600 Wall Street Mobile, Alabama 36695 NOTICE OF ANNUAL MEETING OF STOCKHOLDERS TO BE HELD MONDAY, APRIL 30, 2018 To Our Stockholders: NOTICE IS HEREBY GIVEN that the 2018 Annual Meeting of Stockholders of Computer Programs and Systems, Inc. (the “Company”) will be held at 8:00 a.m., Central Time, on Monday, April 30, 2018, at The Battle House Renaissance Mobile Hotel & Spa, 26 North Royal Street, Mobile, Alabama 36602. Directions to attend the annual meeting where you may vote in person can be found on our website at http://investors.cpsi.com . The annual meeting is being held for the following purposes: 1. To elect three Class I directors to serve on the Board of Directors of the Company for a three-year term expiring at the 2021 Annual Meeting of Stockholders; 2. To approve on a non-binding advisory basis the compensation of the Company’s named executive officers (“NEOs”); 3. To ratify the appointment of Grant Thornton LLP as the Company’s independent registered public accountants for the year ending December 31, 2018; and 4. To transact such other business as may properly come before the annual meeting or any adjournment thereof. The Board of Directors recommends that you vote FOR each of the three director nominees; FOR the approval on an advisory basis of the compensation of our NEOs; and FOR the ratification of the appointment of Grant Thornton LLP as the Company’s independent registered public accountants for the year ending December 31, 2018. The annual meeting may be adjourned from time to time without notice other than announcement at the meeting or at adjournments thereof, and any business for which notice is hereby given may be transacted at any such adjournment. The Board of Directors has set March 5, 2018 as the record date for the annual meeting. Only holders of record of the Company’s common stock at the close of business on the record date will be entitled to notice of, and to vote at, the annual meeting. Whether or not you plan to attend the annual meeting, we urge you to review these materials carefully, which are available at www.proxydocs.com/CPSI , and to vote by one of the following means. • By Internet: Go to the website www.proxypush.com/CPSI and follow the instructions. You will need the control number included on your Notice of Internet Availability of Proxy Materials to obtain your records and create an electronic voting instruction form. • By Telephone: From a touch-tone telephone, dial toll-free 1-866-509-1050 and follow the recorded instructions. You will need the control number included on your Notice of Internet Availability of Proxy Materials in order to vote by telephone. • By Mail: You may request from the Company a hard copy of the proxy materials, including a proxy card, by following the instructions on your Notice of Internet Availability of Proxy Materials. If you request and receive a proxy card, please mark your selections on the proxy card, date and sign your name exactly as it appears on the proxy card and mail the proxy card in the pre-paid envelope that will be provided to you. Mailed proxy cards must be received no later than April 29, 2018 in order to be counted for the annual meeting. By order of the Board of Directors, David A. Dye Chairman of the Board This Proxy Statement and the accompanying instruction form or proxy card are being made available on or about March 16, 2018.