AKAO 2018 Proxy Statement

23 DIRECTOR COMPENSATION Pursuant to our Non-Employee Director Compensation Program, our non-employee directors receive cash compensation, paid quarterly in arrears, as follows: • Each non-employee director receives an annual cash retainer in the amount of $35,000 per year. • The Non-Executive Chairperson receives an additional annual cash retainer in the amount of $27,500 per year. • The chairperson of the audit committee receives additional annual cash compensation in the amount of $15,000 per year for such chairperson’s service on the audit committee. Each non-chairperson member of the audit committee receives additional annual cash compensation in the amount of $7,500 per year for such member’s service on the audit committee. • The chairperson of the compensation committee receives additional annual cash compensation in the amount of $10,000 per year for such chairperson’s service on the compensation committee. Each non-chairperson member of the compensation committee receives additional annual cash compensation in the amount of $5,000 per year for such member’s service on the compensation committee. • The chairperson of the nominating and corporate governance committee receives additional annual cash compensation in the amount of $7,000 per year for such chairperson’s service on the nominating and corporate governance committee. Each non-chairperson member of the nominating and corporate governance committee receives additional annual cash compensation in the amount of $3,000 per year for such member’s service on the nominating and corporate governance committee. Under the Non-Employee Director Compensation Program, each non-employee director receives an option to purchase 20,000 shares of our common stock upon the director’s initial appointment or election to our board of directors (“Board”), referred to as the Initial Grant, and an annual option to purchase 10,000 shares of our common stock on the date of each annual stockholder’s meeting thereafter, referred to as the Annual Grant. The Initial Grant will vest as to 1/36th of the shares subject to Initial Grant each month following the applicable grant date, subject to continued service through each applicable vesting date. The Annual Grant will vest as to 1/12th of the shares subject to the Annual Grant each month following the applicable grant date, which vesting will accelerate in full on the date of the next annual stockholder’s meeting to the extent unvested as of such date, subject to continued service through each applicable vesting date. The table below sets forth information regarding the compensation of our non-employee directors for the fiscal year ended December 31, 2017. Name of Non-Employee Director Fees Earned or Paid in Cash ($) Option Awards (1) ($) Total ($) Karen Bernstein, Ph.D. (2) 22,750 310,342 (4) 333,092 Alan B. Colowick, M.P.H., M.D. (2) 30,625 — 30,625 John C. Doyle 42,500 142,434 184,934 Michael Fischbach, Ph.D. 38,000 142,434 180.434 Halley E. Gilbert (3) 42,500 349,572 (4) 392,072 Kent E. Lieginger, Pharm.D. 42,000 142,434 184,434 Bryan E. Roberts, Ph.D. 64,375 142,434 206,809 John W. Smither 55,000 142,434 197,434 Gregory Stea 39,000 142,434 181,434

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