AKAO 2018 Proxy Statement

40 Option Awards Stock Awards Name Vesting Commencement Date Number of Securities Underlying Unexercised Options (#) Exercisable Number of Securities Underlying Unexercised Options (#) Unexercisable Equity Incentive Plan Awards: Number of Securities Underlying Unexercised Unearned Options (#) Option Exercise Price ($) Option Expiration Date Number of Shares or Units of Stock That Have Not Vested (#) Market Value of Shares or Units of Stock That Have Not Vested ($) (1) Equity Incentive Plan Awards: Number of Unearned Shares, Units or Other Rights That Have Not Vested (#) Equity Incentive Plan Awards: Market or Payout Value of Unearned Shares, Units or Other Rights That Have Not Vested ($) (1) — — — — — — — — 1,800 (8) 19,332 Ian Friedland, M.D. 9/25/2014 31,670 — — 8.04 9/30/2018 — — — — 2/5/2015 30,042 — — 11.78 9/30/2018 — — — — 2/26/2016 11,110 — — 3.65 9/30/2018 — — — — 2/26/2016 8,000 — — 3.65 9/30/2018 — — — — 3/14/2017 18,279 — — 8.04 9/30/2018 — — — — 3/14/2017 9,657 — — 11.78 9/30/2018 — — — — 3/14/2017 8,253 — — 3.65 9/30/2018 — — — — (1) The dollar amounts shown are determined by multiplying the number of unvested units by $10.74, the closing price of the Company’s common stock on December 29, 2017. (2) The option is exercisable immediately, in whole or in part, conditioned upon Dr. Hillan entering into a restricted stock purchase agreement with respect to any unvested shares. The shares subject to the option vest and/or are released from the Company’s repurchase option, as to 47,472 of the shares subject to the option on the date that the closing trading price of the Company’s common stock first reaches or exceeds $33.00 per share, as to 47,472 of the shares subject to the option on the date that the closing trading price of the Company’s common stock first reaches or exceeds $55.00 per share, and as to 5,656 of the shares subject to the option on the date that the closing trading price of the Company’s common stock first reaches or exceeds $77.00 per share (in each case, as appropriately adjusted for stock splits, stock dividends, recapitalizations and the like) respectively, subject to Dr. Hillan continuing to provide services to the Company through such vesting date. (3) The option is exercisable immediately, in whole or in part, conditioned upon Dr. Hillan entering into a restricted stock purchase agreement with respect to any unvested shares. The shares subject to the option vest and/or are released from the Company’s repurchase option, as to one-third of the shares subject to the option on the date that the closing trading price of the Company’s common stock first reaches or exceeds each of $33.00, $55.00 and $77.00 per share (in each case, as appropriately adjusted for stock splits, stock dividends, recapitalizations and the like) respectively, subject to Dr. Hillan continuing to provide services to the Company through such vesting date. (4) The shares subject to the option vest and become exercisable as to 1/48 th of the shares subject to the option on each monthly anniversary of the vesting commencement date, such that all shares will be vested and exercisable on the fourth anniversary of the vesting commencement date, subject to the holder continuing to provide services to the Company through such vesting date. (5) The restricted stock units shall vest as to 1/4 th of the shares on each annual anniversary of the vesting commencement date, so that 100% of the restricted stock units are vested on the fourth anniversary of the vesting commencement date, subject to the holder continuing to provide services to the company through each vesting date. (6) The shares subject to the option vest as to 40% of the shares subject to the option on 30th consecutive date that the closing trading price of the Company’s common stock is at least $12.00 per share, as to 40% of the shares subject to the option on the 30th consecutive date that the closing trading price of the Company’s common stock is at least $25.00 per share, and as to 20% of the shares subject to the option on the 30th consecutive date that the closing trading price of the Company’s common stock is at least $55.00 per share (in each case, as appropriately adjusted for stock splits, stock dividends, recapitalizations and the like), subject to the NEO continuing to provide services to the Company through such vesting date. (7) 100% of the shares subject to the option will vest on the 30th consecutive date that the closing trading price of the Company’s common stock is at least $25.00 per share (as appropriately adjusted for stock splits, stock dividends, recapitalizations and the like), subject to the NEO continuing to provide services to the Company through such vesting date. (8) The restricted stock units vest as to 40% of the restricted stock units on the 30th consecutive date that the closing trading price of the Company’s common stock is at least $12.00 per share, as to 40% of the restricted stock units on the 30th consecutive date that the closing trading price of the Company’s common stock is at least $25.00 per share, and as to 20% of the restricted stock units on the 30th consecutive date that the closing trading price of the Company’s common stock is at least $55.00 per share (in each case, as appropriately adjusted for stock splits, stock dividends, recapitalizations and the like), subject to the NEO continuing to provide services to the Company through such vesting date. (9) 100% of the restricted stock units will vest on the 30th consecutive date that the closing trading price of the Company’s common stock is at least $25.00 per share (as appropriately adjusted for stock splits, stock dividends, recapitalizations and the like), subject to the NEO continuing to provide services to the Company through such vesting date. (10) The shares subject to the option vest and become exercisable as to 1/4th of the shares subject to the option on the first anniversary of the vesting commencement date, and thereafter as to 1/48th of the shares subject to the option on each monthly anniversary of the vesting commencement date, such that all shares will be vested and exercisable on the fourth anniversary of the vesting commencement date, subject to the holder continuing to provide services to the Company through such vesting date. (11) The shares subject to the option vest as to 40% of the shares subject to the option on 30th consecutive date that the closing trading price of the Company’s common stock is at least $30.00 per share, as to 40% of the shares subject to the option on the 30th consecutive date that the closing trading price of the Company’s common stock is at least $40.00 per share, and as to 20% of the shares subject to the option on the 30th consecutive date that the closing trading price of the Company’s common stock is at least $55.00 per share (in each case, as appropriately adjusted for stock splits, stock dividends, recapitalizations and the like), subject to the NEO continuing to provide services to the Company through such vesting date.

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