AKAO 2018 Proxy Statement

49 (3) As reported on Amendment No. 1 to Schedule 13D filed with the SEC on December 22, 2016 by Growth Equity Opportunities Fund IV, LLC (“GEO”), New Enterprise Associates 15, L.P. (“NEA 15”), NEA Partners 15, L.P. (“NEA Partners 15”), NEA 15 GP, LLC (“NEA 15 LLC”), Peter J. Barris, Forest Baskett, Anthony A. Florence, Jr., Krishna S. Kolluri, Joshua Makower, David M. Mott, Jon M. Sakoda, Scott D. Sandell, Peter W. Sonsini and Ravi Viswanathan. GEO is the sole record owner of the 5,215,128 shares and 1,178,782 shares of common stock that may be acquired upon exercise of a warrant held by GEO. The warrant may not be exercised to the extent such exercise would cause the holder of such warrant (together with the holder’s affiliates, and any other persons acting as a group together with the holder or any of the holder’s affiliates) to beneficially own more than 19.99% of the shares of our common stock then outstanding, provided, that the holder of the warrant has a contractual right to change the 19.99% limitation to any other percentage (in no event to exceed 19.99%). As the sole member of GEO, NEA 15 may be deemed to beneficially own the shares listed herein. As the general partner of NEA 15, NEA Partners 15 may be deemed to beneficially own the shares listed herein. As the sole general partner of NEA Partners 15, NEA 15 LLC may be deemed to beneficially own the shares listed herein. As the individual managers of NEA 15 LLC (the “NEA 15 Managers”), Messrs. Barris, Baskett, Florence, Kolluri, Makower, Mott, Sakoda, Sandell, Sonsini, and Viswanathan may be deemed to beneficially own the shares listed herein. NEA 15, NEA Partners 15, NEA 15 LLC and the NEA 15 Managers share voting and dispositive power with regard to the shares owned of record by GEO. Each of GEO, NEA 15, NEA Partners 15, NEA 15 LLC and the NEA 15 Managers disclaims beneficial ownership of the reported shares other than those shares which such person owns of record. The address for each of GEO, NEA 15, NEA Partners 15 and NEA 15 LLC is New Enterprise Associates, 1954 Greenspring Drive, Suite 600 Timonium, MD 21093. The address for each of Messrs. Barris, Florence and Mott is New Enterprise Associates, 5425 Wisconsin Avenue, Suite 800, Chevy Chase, MD 20815. The address for each of Messrs. Baskett, Kolluri, Makower, Sakoda, Sandell, Sonsini and Viswanathan is New Enterprise Associates, 2855 Sand Hill Road, Menlo Park, CA 94025. (4) As reported on Amendment No. 4 to Schedule 13G filed with the SEC on February 13, 2018 by FMR LLC (“FMR”). FMR has sole voting power over 1,814,762 shares and shared dispositive power over shares listed herein. Abigail P. Johnson and members of the Johnson family control 49% of FMR and have shared voting and dispositive power over the shares listed herein. Fidelity Institutional Asset Management Trust Company (formerly known as Pyramis Global Advisors Trust Company), an indirect wholly-owned subsidiary of FMR and an investment advisor to various investment companies, is the beneficial owner of the shares listed herein. The address for FMR is 245 Summer Street, Boston, MA 02210. (5) As reported on Schedule 13G filed with the SEC on February 1, 2018 by BlackRock, Inc. BlackRock, Inc. has sole voting power over 2,772,787 shares and sole dispositive power over the shares listed herein. The address for BlackRock, Inc. is 55 East 52nd Street, New York, NY 10055. (6) As reported on Schedule 13G filed with the SEC on February 13, 2018 by State Street Corporation. State Street Corporation has shared voting and dispositive power over the shares listed herein. The address for State Street Corporation is One Lincoln Street, Boston, MA 02111. (7) As reported on Amendment No. 1 to Schedule 13G filed with the SEC on February 13, 2018 by Foresite Capital Fund III, L.P. (“Foresite Capital III”), Foresite Capital Management III, LLC (Foresite Management III”) and James Tananbaum. Foresite Capital III holds the shares listed herein. Foresite Management III is the general partner of Foresite Capital III and may be deemed to have sole voting and dispositive power over the shares held by Foresite Capital III. Mr. Tananbaum is the managing member of Foresite Management III and, in his capacity as such, may be deemed to have sole voting and dispositive power with respect to such shares. The address for Foresite Capital III, Foresite Management III and Mr. Tananbaum is c/o Foresite Capital Management, 600 Montgomery Street, Suite 4500, San Francisco, CA 94111. (8) Consists of (i) 25,945 shares held directly by Mr. Wise, (ii) 178,416 shares held by the Blake A. Wise Living Trust (the “Wise Trust”) and (iii) 155,705 shares that may be acquired pursuant to the exercise of stock options within 60 days of March 31, 2018. (9) Consists of (i) 33,651 shares held directly by Dr. Hillan and (ii) 771,792 shares that may be acquired pursuant to the exercise of stock options within 60 days of March 31, 2018. (10) Consists of (i) 9,960 shares held directly by Mr. Schilke and (ii) 73,983 shares that may be acquired pursuant to the exercise of stock options within 60 days of March 31, 2018.