AKAO 2018 Proxy Statement

50 (11) Consists of (i) 14,932 shares held directly by Dr. Swem and (ii) 84,457 shares that may be acquired pursuant to the exercise of stock options within 60 days of March 31, 2018. (12) Consists of (i) 3,707 shares held directly by Mr. Loeb and (ii) 29,225 shares that may be acquired pursuant to the exercise of stock options within 60 days of March 31, 2018. (13) Consists of (i) 86,426 shares held directly by Dr. Friedland and (ii) 117,021 shares that may be acquired pursuant to the exercise of stock options within 60 days of March 31, 2018. (14) Consists of (i) 1,421,623 shares of common stock held by Venrock Associates IV, L.P. (“VA IV”), (ii) 289,912 shares held by Venrock Partners, L.P. (“VP”), (iii) 34,926 shares of common stock held by Venrock Entrepreneurs Fund IV, L.P. (“VEF”) and (iv) 39,166 shares that may be acquired pursuant to the exercise of stock options within 60 days of March 31, 2018 held by Dr. Roberts. Venrock Partners Management, LLC (“VPM”) is the general partner of VP, Venrock Management IV, LLC (“VA IVM”) is the general partner of VA IV and VEF Management IV, LLC (“VEFM”) is the general partner of VEF. VP, VA IV, VEF, VPM, VA IVM and VEFM have shared voting and dispositive power over the shares held by VP, VA IV and VEF. Dr. Roberts is a member of each of VA IVM, VPM and VEFM and may therefore be deemed to have voting and dispositive power with respect to the shares held by VP, VA IV and VEF, but each of Dr. Roberts, VA IVM, VPM and VEFM disclaims beneficial ownership of the shares held by VP, VA IV and VEF, except to the extent of their respective pecuniary interests therein. (15) Consists of 5,555 shares that may be acquired pursuant to the exercise of stock options within 60 days of March 31, 2018. (16) Consists of 35,832 shares that may be acquired pursuant to the exercise of stock options within 60 days of March 31, 2018. (17) Consists of 127,280 shares that may be acquired pursuant to the exercise of stock options within 60 days of March 31, 2018. (18) Consists of 18,054 shares that may be acquired pursuant to the exercise of stock options within 60 days of March 31, 2018. (19) Consists of 39,166 shares that may be acquired pursuant to the exercise of stock options within 60 days of March 31, 2018. (20) Consists 127,280 shares that may be acquired pursuant to the exercise of stock options within 60 days of March 31, 2018. (21) Consists of 38,610 shares that may be acquired pursuant to the exercise of stock options within 60 days of March 31, 2018. (22) Consists of: (i) 2,013,072 shares held by our executive officers and by entities affiliated with Dr. Roberts and Mr. Wise and (ii) 1,476,172 shares that may be acquired by our current executive officers and directors pursuant to the exercise of stock options within 60 days of March 31, 2018. Section 16(a) Beneficial Ownership Reporting Compliance Section 16(a) of the Exchange Act requires the Company’s directors and executive officers, and persons who own more than 10% of a registered class of the Company’s equity securities, to file with the SEC initial reports of ownership and reports of changes in ownership of common stock and other equity securities of the Company. Officers, directors and greater than 10% beneficial owners are required by SEC regulations to furnish the Company with copies of all Section 16(a) forms they file. To the Company’s knowledge, based solely on a review of the copies of such reports furnished to the Company and written representations that no other reports were required, during the year ended December 31, 2017, none of our directors, officers or greater than 10% beneficial owners failed to file on a timely basis any reports required by Section 16(a) of the Exchange Act.