APLS 2018 Proxy Statement

As of December 31, 2017, our non-employee directors held the following stock options, all of which were granted under our 2010 Plan or 2017 Plan: Name Option Awards Gerald Chan, D.Sc. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 121,894 A. Sinclair Dunlop . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 121,894 Alec Machiels . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 309,423 Stephanie Monaghan O’Brien . . . . . . . . . . . . . . . . . . . . . 121,894 Securities Authorized for Issuance Under Equity Compensation Plans The following table contains information about our equity compensation plans as of December 31, 2017. As of December 31, 2017, we had three equity compensation plans, each of which was approved by our stockholders: our 2010 equity incentive plan, or the 2010 Plan, our 2017 stock incentive plan, or the 2017 Plan and our 2017 employee stock purchase plan, or the 2017 ESPP. As of December 31, 2017 Plan Category Number of securities to be issued upon exercise of outstanding options, warrants and rights Weighted average exercise price of outstanding options, warrants and rights Number of securities remaining available for future issuance under equity compensation plans (excluding securities reflected in column (a)) (a) (b) (c) Equity compensation plans approved by security holders(1)(2)(3) . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 6,355,581 $4.78 1,144,859 Equity compensation plans not approved by security holders . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . — — — Total . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 6,355,581 4.78 1,144,859 (1) Consists of our 2010 Plan, 2017 Plan and 2017 ESPP. (2) As of December 31, 2017, 1,144,859 shares were available for issuance under our 2017 Plan, which became effective on November 8, 2017, the effective date of our initial public offering. The number of shares of our common stock reserved for issuance under the 2017 Plan will be increased (i) from time to time by the number of shares of our common stock subject to outstanding awards under our 2010 Plan that expire, terminate or are otherwise surrendered, cancelled, forfeited or repurchased by us at their original issuance price pursuant to a contractual repurchase right, and (ii) annually on the first day of each fiscal year, beginning with the fiscal year ending December 31, 2018 and continuing until, and including, the fiscal year ending December 31, 2027, equal to the lowest of (a) 4,219,409 shares of our common stock, (b) 4.0% of the number of shares of our common stock outstanding on the first day of the fiscal year and (c) an amount determined by our board of directors. On January 1, 2018, an additional 2,023,366 shares of our common stock were reserved for issuance under the 2017 Plan pursuant to this provision, which shares are not reflected in the number of shares available for issuance under the 2017 Plan in the table above. (3) As of December 31, 2017, 468,823 shares were reserved for issuance under our 2017 ESPP, which became effective on November 8, 2017, the effective date of our initial public offering. The number of shares of our common stock reserved for issuance under the 2017 ESPP will automatically increase on the first day of each fiscal year, beginning with the fiscal year ending December 31, 2018 and continuing until, and including, the fiscal year ending December 31, 2027, equal to the lowest of (i) 937,646 shares of our common stock, (ii) 1.0% of the number of shares of our common stock outstanding on the first day of the fiscal year and (iii) an amount determined by our board of directors. No shares have been issued from the 2017 ESPP. On January 1, 2018, an additional 503,341 shares of our common stock were reserved for issuance under the ESPP Plan pursuant to this provision, which shares are not reflected in the number of shares available for issuance under the 2017 ESPP in the table above. - 23 -