APLS 2018 Proxy Statement

IMPORTANT INFORMATION ABOUT THE ANNUAL MEETING AND VOTING Purpose of the Annual Meeting At the Annual Meeting, our stockholders will consider and vote on the following matters: 1. to elect one Class I director to hold office until the 2021 annual meeting of stockholders; 2. to ratify the appointment of Ernst & Young LLP as our independent registered public accounting firm for the fiscal year ending December 31, 2018; and 3. to transact any other business that may properly come before the annual meeting or any adjournment or postponement thereof. As of the date of this proxy statement, we are not aware of any business to come before the meeting other than the first two items noted above. Board of Directors Recommendation Our board of directors unanimously recommends that you vote: FOR the election of one Class I director to serve as the class I director on our board of directors for a three- year term; and FOR the ratification of the appointment of Ernst & Young LLP as our independent registered public accounting firm for the fiscal year ending December 31, 2018. Availability of Proxy Materials The proxy materials, including this proxy statement, a proxy card and our 2017 Annual Report are available for viewing, printing and downloading on the Internet at https://www.proxydocs.com/APLS. Who Can Vote at the Annual Meeting Only stockholders of record at the close of business on the record date of April 10, 2018, are entitled to receive notice of the Annual Meeting and to vote the shares of our common stock that they held on that date. As of April 10, 2018, there were 50,433,396 shares of common stock issued and outstanding. Each share of common stock is entitled to one vote on each matter properly brought before the Annual Meeting. Difference between a “stockholder of record” and a beneficial owner of shares held in “street name” Stockholder of Record . If your shares are registered directly in your name with our transfer agent, Computershare, then you are considered a “stockholder of record” of those shares. In this case, your Notice has been sent to you directly by us. You may vote your shares by proxy prior to the Annual Meeting by following the instructions contained in the Notice and in the section titled “How to Vote” on page 3 of this proxy statement. Beneficial Owners of Shares Held in Street Name . If your shares are held in a brokerage account or by a bank, trust or other nominee or custodian, then you are considered the beneficial owner of those shares, which are held in “street name.” In this case, your Notice will be forwarded to you by that organization. The organization holding your account is considered the stockholder of record for purposes of voting at the Annual Meeting. As the beneficial owner, you have the right to instruct that organization as to how to vote the shares held in your account by following the instructions contained on the voting instruction card provided to you by that organization. - 2 -