APLS 2018 Proxy Statement

PRINCIPAL STOCKHOLDERS Unless otherwise provided below, the following table sets forth information with respect to the beneficial ownership of our common stock as of March 31, 2018 by: • each of our directors; • our named executive officers; • all of our directors and executive officers as a group; and • each person, or group of affiliated persons, who is known to us to be the beneficial owner of 5% or more of the outstanding shares of our common stock The column entitled “Percentage Beneficially Owned” is based on a total of 50,429,020 shares of our common stock outstanding as of March 31, 2018. Beneficial ownership is determined in accordance with the rules and regulations of the SEC and includes voting or investment power with respect to our common stock. Shares of our common stock subject to options or warrants that are currently exercisable or exercisable within 60 days after March 31, 2018 are considered outstanding and beneficially owned by the person holding the options for the purpose of calculating the percentage ownership of that person but not for the purpose of calculating the percentage ownership of any other person. Except as otherwise noted, the persons and entities in this table have sole voting and investing power with respect to all of the shares of our common stock beneficially owned by them, subject to community property laws, where applicable. Except as otherwise set forth below, the address of the beneficial owner is c/o Apellis Pharmaceuticals, Inc., 6400 Westwind Way, Suite A, Crestwood, Kentucky 40014. Name of Beneficial Owner Number of Shares Beneficially Owned Percentage Beneficially Owned 5% Stockholders Morningside Venture Investments, Ltd.(1) . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 11,353,303 22.5 Potentia Holdings, LLC(2) . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 3,826,601 7.6 venBio Global Strategic Fund II LP(3) . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 3,579,305 7.1 Cormorant Funds(4) . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 3,768,756 7.5 Hillhouse Funds(5) . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 3,527,152 7.0 Named Executive Officers and Directors Cedric Francois, M.D., Ph.D.(6)(12) . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 1,747,849 3.4 Pascal Deschatelets, Ph.D.(7)(12) . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 1,322,327 2.6 Timothy Sullivan . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . — — Gerald Chan(8) . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 91,421 * A. Sinclair Dunlop(9) . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 678,473 1.3 Alec Machiels(10)(12) . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 895,006 1.8 Stephanie Monaghan O’Brien(11) . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 91,421 * All Executive Officers and Directors as a Group ( 11 persons) (12) . . . . . . . . . . . . . . 4,956,366 9.3 *Represents beneficial ownership of less than 1% of our outstanding stock. (1) Louise Mary Garbarino, Jill Marie Franklin, Peter Stuart Allenby Edwards and Raymond Long Sing Tang, the directors of MVIL, share voting and dispositive control over the shares held by MVIL. The address for MVIL is 2nd Floor, Le Prince de Galles, 3-5 Avenue des Citronniers, MC 98000, Monaco. (2) Potentia’s board of directors has voting and dispositive control over the shares held by Potentia. The members of the Potentia board of directors are Cedric Francois, Alec Machiels, David Darst Jr., Stephen Gilles, Marie-Claude Bernal, Doug Onsi and Sinclair Dunlop. Because the board of directors acts by majority approval, none of the members of Potentia’s board of directors has individual voting or - 27 -