APLS 2018 Proxy Statement

investment power with respect to such shares. We expect that Potentia may distribute the shares of our common stock it holds to its stockholders at a future time after the closing of this offering. See “Transactions with Related Persons” for more information. (3) venBio Global Strategic GP II, L.P., or the General Partner, is the sole general partner of venBio Global Strategic Fund II LP, or venBio. venBio Global Strategic GP II, Ltd., or GP Ltd., is the sole general partner of the General Partner. Robert Adelman and Corey Goodman are directors of the GP Ltd. As the sole general partner of the Fund, the General Partner may be deemed to own beneficially the venBio Shares. As the sole general partner of the General Partner, the GP Ltd. likewise may be deemed to own beneficially the venBio Shares. As directors of the GP Ltd., each of the Directors likewise may be deemed to own beneficially the venBio Shares. The address for venBio, the General Partner and GP Ltd. is c/o venBio Partners, LLC, 1700 Owens Street, Suite 595, San Francisco, CA 94158. We obtained the information regarding beneficial ownership of these shares solely from a Schedule 13G that was filed with the SEC on February 9, 2018. (4) Consists of shares of common stock beneficially owned by Cormorant Global Healthcare Master Fund, LP, or the Master Fund, and shares of common stock beneficially owned by Cormorant Private Healthcare Fund I, LP, or Fund I, and a managed account, or the Account. Cormorant Global Healthcare GP, LLC serves as the general partner of the Master Fund. Cormorant Asset Management, LLC serves as the investment manager to the Master Fund, Fund I and the Account. Bihua Chen serves as the managing member of Cormorant Global Healthcare GP, LLC and Cormorant Asset Management, LLC and may be deemed to have sole voting and investment power of the securities held by the Master Fund, Fund I and the Account. The address of the Master Fund, Fund I, the Account and Cormorant Asset Management, LLC is 200 Clarendon Street, 52nd Floor, Boston, MA 02116. We obtained the information regarding beneficial ownership of these shares solely from the Amendment No. 1 to Schedule 13G that was filed with the SEC on February 14, 2018. (5) Consists of shares of common stock beneficially owned by Hillhouse WHP Holdings Limited, or WHP, Gaoling Fund, L.P., or Gaoling, and YHG Investment, L.P., or YHG. WHP is owned by Hillhouse Fund II, L.P., or Fund II. Hillhouse Capital Management, Ltd., or Hillhouse Capital, acts as the sole management company of Fund II and Gaoling and sole general partner of YHG. Hillhouse Capital is deemed to be the sole beneficial owner of, and to solely control the voting and investment power of, the shares of Common Stock held by Fund II, Gaoling and YHG. The address for Hillhouse Capital is Suite 1608, One Exchange Square, 8 Connaught Place, Hong Kong. We obtained the information regarding beneficial ownership of these shares solely from a Schedule 13G that was filed with the SEC on February 14, 2018. (6) Consists of (i) 329,996 shares of common stock held by Dr. Francois, (ii) 234,411 shares of common stock held by The Francois-DuBois Educational Trust, as to which Mr. Machiels holds a voting proxy and for which Fiduciary Trust Company of New England serves as trustee, and (iii) 1,183,442 shares of common stock issuable upon the exercise of options exercisable within 60 days after March 31, 2018. (7) Consists of (i) 561,452 shares of common stock and (ii) 760,875 shares of common stock issuable upon the exercise of options exercisable within 60 days after March 31, 2018. (8) Consists of 91,421 shares of common stock issuable upon the exercise of options exercisable within 60 days after March 31, 2018. (9) Consists of (i) 587,052 shares of common stock held by affiliated entities and (ii) 91,421 shares of common stock issuable upon the exercise of options exercisable within 60 days after March 31, 2018. (10) Consists of (i) 381,325 shares of common stock; (ii) 234,411 shares of common stock held by The Francois-DuBois Educational Trust, as to which Mr. Machiels holds a voting proxy, and (iii) 278,950 shares of common stock issuable upon the exercise of options exercisable within 60 days after March 31, 2018. (11) Consists of 91,421 shares of common stock issuable upon the exercise of options exercisable within 60 days after March 31, 2018. (12) See “Transactions with Related Persons” for information regarding the possible distribution of a portion of the shares of our common stock held by Potentia to Drs. Francois and Deschatelets, and Messrs. Machiels and Dunlop, which shares are not reflected in these beneficial ownership amounts. - 28 -